Stéphane Oliet, Neurocentre Magendie, Bordeaux Neurocampus, CNRS, France
Regulation of NMDA receptor activity by astrocytes
Stéphane Oliet is a neurophysiologist who is investigating neuron-glia interactions in the healthy and diseased brain. He received his PhD from McGill University and was trained as a postodoctoral fellow at UCSF. He was recruited at the CNRS as a permanent scientist in 1997. He is presently serving as the Director of the Neurocentre Magendie in Bordeaux. His work has contributed to the emerging concept of the tripartite synapse that considers astrocytes as active players of cerebral communication. In particular, he showed that the astrocytic environment of neurons and synapses plays a key role in shaping excitation through glutamate uptake. He also characterized glia-derived D-serine as an essential component of NMDA receptor activation, a mechanism by which astrocytes regulate synaptic plasticity and memory.