Université de Bordeaux
BrainConf: Synaptic Plasticity27-30 September, 2022 - Bordeaux

Johannes W. Hell

Johannes W. Hell, Department of Pharmacology, University of California at Davis, USA


Calcium/calmodulin - sensitive anchoring of PSD-95 and AMPARs by alpha-actinin in spines    


My B.S. was in organic synthesis (stereoselective peptide and sugar syntheses; Tübingen 1982).

My ‘Diplom’ (M.S.; Dr. Stadler) was to develop a new method to isolate synaptic vesicles (Göttingen, 1987).

In my Ph.D. with R. Jahn, I showed for the very first time GABA uptake by synaptic vesicles after developing a new procedure for synaptic vesicle isolation (Munich, 1991).

During my post-doctoral work with W. Catterall, I focused on Ca channels and expanded my skills in protein analytic and purification, molecular and cell biology and electrophysiology (Seattle, WA, USA, 1995).

My strengths are a deep mechanistic understanding of synaptic functions, ligand- and voltage-gated ion channels, signaling by GPCRs and kinases, and the multidisciplinary use of cutting edge molecular, cellular, electrophysiological, and behavioral methods including superresolution microscopy and recording of fEPSP, EPSC, mEPSC and single Ca2+ channels. Many of my peer-reviewed publications (total of >150 including co-authorships and reviews) are in journals that demand highly comprehensive projects and have impact factors >10 (EMBO J., Neuron, Nature, Science), many cited >50 if not >100 times (my total citations are ~14,000).

Website: https://biology.ucdavis.edu/people/johannes-hell