Ingo Greger, Neurobiology Division, MRC Laboratory of Molecular Biology, UK
Mechanisms underlying activation and modulation of AMPA receptor complexes
Ingo Greger obtained his PhD in 1998 fromthe University of Oxford (UK), where he investigatedmechanisms of gene expression in NickProudfoot’s lab, using yeast as a model system. In 1999 he moved to Ed Ziff’s lab at theNYU School of Medicine & HHMI. In Ed’s lab he started his work onAMPA receptors, investigating their biogenesis and trafficking mechanisms from the endoplasmic reticulum. Back in the UK, he continuedhis work on glutamate receptors whilst a RoyalSociety fellow at the MRC LMB in Cambridge,from 2003-2006. At the LMB he added structural approaches (X-ray crystallography) and patch-clamp electrophysiology to his tool box.
He is currently a senior MRCinvestigator at the LMB. His lab studiesAMPA receptor operation at various levelsof complexity, using a combination of structural, functional and imaging approaches. His ultimate aim is to understand AMPAR receptor signalling at the atomic level, and how glutamate receptor regulation at synapses contributes to learning.