Christophe Mulle, Institute for Interdisciplinary Neuroscience, Bordeaux Neurocampus, CNRS, France
Presynaptic plasticity in hippocampal circuits
Christophe Mulle is a cellular neurobiologist with expertise in electrophysiology of synaptic transmission. He identified and characterized functional nicotinic receptors in the mammalian brain while working in the laboratory of Jean-Pierre Changeux at the Pasteur Institute. Following a post-doc at the Salk Institute in the laboratory of Steve Heinemann, he has guided since 1995 a team which has pioneered the role of the elusive kainate receptors in brain function and has described the molecular events that govern their polarized trafficking. The team currently investigates the properties of hippocampal synaptic circuits and how these properties allow to process and encode contextual information. A strong focus is given to the mechanisms and integrated consequences of presynaptic plasticity at identified synapses in physiological conditions and in Alzheimer’s disease. The team addresses these mechanisms in mice as well as in human cortical circuits by developing organotypic cortical slices obtained from surgical resections which are amenable to gene targeting methods in combination with cellular electrophysiology. In parallel, Christophe Mulle, in collaboration with Valérie Crépel, is a scientific founder of Corlieve Therapeutics, a company which develops gene therapies targeting aberrant kainate receptors to cure intractable temporal lobe epilepsy.