Université de Bordeaux
BrainConf: Synaptic Plasticity27-30 September, 2022 - Bordeaux

Annalisa Scimemi

Annalisa Scimemi, Department of Biology, SUNY Albany, USA


Circadian cycles change the rules of synaptic plasticity 


The brain regulates every aspect of our daily life, yet many of the fundamental mechanisms underlying its function remain unclear. How do neurons in the brain exchange information among each other? How is their activity conveyed across neurons in different brain regions and how is it shaped by astrocytes?nbsp;In our lab, we are interested in understanding the functional properties of central synapses, the specialized structures that convert the electrical activity of a neuron into a chemical signal for its target cells. We want to understand how individual molecules are distributed within the synapse and how their spatial arrangement influences the properties of neurotransmitter release. We want to know how neurotransmitters diffuse outside of the synapse and generate long-distance signals to different cells. Our ultimate goal is to gain insights into the functional consequences of changes in synaptic function associated with the onset of different neuropsychiatric and neurodegenerative disorders. To perform our studies, we use a combination of experimental and theoretical approaches, including electrophysiology, optogenetics, two-photon imaging and reaction-diffusion computer simulations. We are also eager to learn and develop novel experimental approaches and research tools.

Dr. Scimemi got her PhD in Biophysics from the International School of Advanced Studies (SISSA/ISAS) working with John Nicholls and Enrico Cherubini. She continued her postdoctoral studies with Dr. Dimitri Kullmann (UCL) and Jeff Diamond (NIH). She got her faculty position at SUNY Albany in 2013 and is currently an Associate Professor in the Department of Biology. 

Website: https://www.albany.edu/biology/faculty/annalisa-scimemi